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Title: The type IVB pili of Salmonella enterica serovar Typhi bind to the cystic fibrosis transmembrane conductance regulator
Authors: Tsui, Inez S. M.
Yip, Cecilia M. C.
Hackett, James A.
Morris, Christina J.
Keywords: Salmonella enterica serovar Typhi
Type IVB pili
PrePilS protein
Cystic fibrosis transmembrane conductance regulator
Issue Date: 2003
Citation: Infection and immunity, v. 71, no. 10, Oct. 2003, p. 6049-6050
Abstract: Salmonella enterica serovar Typhi expresses type IVB pili. We show that the prePilS protein (the soluble precursor form of the structural pilin) interacts with a 15-mer peptide representing the first extracellular domain of the cystic fibrosis transmembrane conductance regulator (CFTR), a recognized human epithelial cell receptor for serovar Typhi (G. B. Pier et al., Nature 393:79-82, 1998). This indicates that after mediating bacterial self-association (C. Morris et al., Infect. Immun. 71:1141-1146, 2003), the pili then act to attach the bacterial clumps to CFTR in the membrane of gut epithelial cells. These sequential type IVB pilus-mediated events cannot be performed by (for example) S. enterica serovar Typhimurium, which may explain why only serovar Typhi causes epidemics of enteric fever in humans.
Rights: Copyright © American Society for Microbiology [Infection and Immunity, v. 71, no. 10, Oct. 2003, p. 6049-6050]
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