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Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/1356
Title: Integration of signals from receptor tyrosine kinases and g protein-coupled receptors
Authors: Lowes, Vicki L.
Ip, Nancy Y.
Wong, Yung-Hou
Keywords: G protein
Receptor
Tyrosine kinase
MAPK
Signaling
Issue Date: 2002
Citation: Neuro-Signals, v. 11, no. 1, Jan-Feb 2002, p. 5-19
Abstract: Activation of G protein-coupled receptors (GPCRs) leads to stimulation of classical G protein signaling pathways. In addition, GPCRs can activate the mitogen-activated protein kinases (MAPKs) such as the extracellular signal-regulated kinases, c-Jun NH2-terminal kinases (JNKs), and p38 MAPKs, and thereby influence cell proliferation, cell differentiation and mitogenesis. Cross talk between GPCRs and receptor tyrosine kinases (RTKs) is an incredibly complex process, and the exact signaling molecules involved are largely dependent on the cell type and the type of receptor that is activated. In this review we investigate recent advances that have been made in understanding the mechanisms of cross talk between GPCRs and RTKs, with a focus on GPCR-mediated activation of the Ras/MAPK pathway, GPCR-induced transactivation of RTKs, GPCR-mediated activation of JNK, and p38 MAPK, integration of signals by RhoGTPases, and activation of G protein signaling pathways by RTKs.
Rights: Neuro-Signals © Copyright (2002) S. Karger AG, Basel. The Journal's web site is located at http://www.karger.com/NSG
URI: http://hdl.handle.net/1783.1/1356
Appears in Collections:BICH Journal/Magazine Articles

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