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http://hdl.handle.net/1783.1/1433
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| Title: | Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-β family |
| Authors: | Morita, Kiyokazu
Chow, King-Lau
Ueno, Naoto |
| Keywords: | TGF-Beta signaling
Caenorhabditis elegans
Body length
CET-1
SMA pathway |
| Issue Date: | 1999 |
| Citation: | Development, v. 126, no. 6, March 1999, p. 1337-1347 |
| Abstract: | We have identified a new member of the TGF-β superfamily, CET-1, from Caenorhabditis elegans, which is expressed in the ventral nerve cord and other neurons. cet-1 null mutants have shortened bodies and male tail abnormal phenotype resembling sma mutants, suggesting cet-1, sma-2, sma-3 and sma-4 share a common pathway. Overexpression experiments demonstrated that cet-1 function requires wild-type sma genes. Interestingly, CET-1 appears to affect body length in a dose-dependent manner. Heterozygotes for cet-1 displayed body lengths ranging between null mutant and wild type, and overexpression of CET-1 in wild-type worms elongated body length close to lon mutants. In male sensory ray patterning, lack of cet-1 function results in ray fusions. Epistasis analysis revealed that mab-21 lies downstream and is negatively regulated by the cet-1/sma pathway in the male tail. Our results show that cet-1 controls diverse biological processes during C. elegans development probably through different target genes. |
| Rights: | Permission is granted by the Company of Biologists Ltd. The paper was published in Development 1999 126 : 1337-1347. |
| URI: | http://hdl.handle.net/1783.1/1433 |
| Appears in Collections: | BIOL Journal/Magazine Articles
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| 1337.pdf | | 922Kb | Adobe PDF | View/Open |
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