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Title: In vivo autofluorescence of nasopharyngeal carcinoma and normal tissue
Authors: Qu, Jianan
Yuen, Po Wing
Huang, Zhijian
Wei, William I.
Keywords: Fluorescence
Issue Date: 2000
Citation: Optical Biopsy III, Robert R. Alfano, Editor, Proceedings of SPIE Vol. 3917, p. 9-15 (2000)
Abstract: An optical imaging and spectroscopy system has been developed for the study of in vivo fluorescence of nasophar[y]ngeal tissue through an endoscope. The system records the fluorescence signal in the imaging plane of the endoscopic system. This allows analyze the characteristics of the light induced fluorescence (LIF) spectra recorded by each pixel of the two dimentional detector which may be used for fluorescence endoscopic imaging. If the endoscope for fluorescence endoscopy is the same as one employed for the in vivo fluorescence study, the algorithms developed to distinquish the diseased tissue from normal tissue based on the in vivo fluorescence study should be highly reliable for fluorescence imaging of lesions. In this work, fluorescence spectra were collected from 27 full term patients. Different algorithms were tested for separation of cancerous lesions from normal tissue. High sensitivity and specificity were achieved.
Rights: Copyright 2000 Society of Photo-Optical Instrumentation Engineers. This paper was published in Optical Biopsy III, Robert R. Alfano, Editor, Proceedings of SPIE Vol. 3917, p. 9-15 (2000) and is made available as an electronic reprint with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
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