HKUST Library Institutional Repository Banner

HKUST Institutional Repository >
Biology >
BIOL Journal/Magazine Articles >

Please use this identifier to cite or link to this item:
Title: mab-7 encodes a novel transmembrane protein that orchestrates sensory ray morphogenesis in C. elegans
Authors: Tsang, Shun-Wa
Nguyen, C. Q.
Hall, D. H.
Chow, King-Lau
Keywords: Nematode
Sensory organ
Transmembrane protein
Issue Date: Dec-2007
Citation: Developmental biology, v. 312, no. 1, Dec. 2007, p. 353-366
Abstract: The tapered sensory rays of the male C. elegans are important for successful male/hermaphrodite copulation. A group of ram (RAy Morphology abnormal) genes encoding modifying enzymes and transmembrane protein have been reported as key regulators controlling ray morphogenesis. Here we report the characterization of another component essential for this morphogenetic process encoded by mab-7. This gene is active in the hypodermis, structural cells, the body seam and several head neurons. It encodes a novel protein with a hydrophobic region at the N-terminus, an EGF-like motif, an ShKT motif and a long C-terminal tail. All these domains are shown to be critical to MAB-7 activity except the EGF-like domain, which appears to be regulatory and dispensable. MAB-7 is shown to be a type II membrane protein, tethered on the cell surface by the N-terminal transmembrane domain with the remainder of the protein exposed to the extracellular matrix. Since ectopic mab-7 expression in any ray cell or even in touch neurons of non-ray lineage can rescue the mutant phenotype, mab-7 is probably acting non-autonomously. It may facilitate intercellular communication among ray cells to augment normal ray morphogenesis.
Rights: Developmental Biology © copyright (2007) Elsevier. The Journal's web site is located at
Appears in Collections:BIOL Journal/Magazine Articles

Files in This Item:

File Description SizeFormat
Tsangetal20070908.pdfpre-published version251KbAdobe PDFView/Open

Find published version via OpenURL Link Resolver

All items in this Repository are protected by copyright, with all rights reserved.