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|Title: ||p35nck5a binding proteins|
|Authors: ||Ching, Yick Pang|
Wang, Jerry H. C.
|Keywords: ||Alzheimer's disease|
|Issue Date: ||22-Jun-2004 |
|Citation: ||US Patent 6,753,413 B1, 2004|
|Abstract: ||Cyclin-dependent protein kinase 5 (Cdk5) has been shown to be involved in neuronal cell differentiation in the form of an active kinase, named neuronal Cdc2-like kinase (Nclk). However, its activity was shown to be suppressed by forming complex with p35nck5a. Therefore, there is a need for identifying the identities of various binding proteins in the macromolecular protein complex.
The present inventors have now succeeded in isolating three novel p35nck5a binding proteins useful for a variety of purposes, particularly as tools to analyze how p35nck5a interacts with other proteins and for drug development for Alzheimer's Disease.
This invention provides a method to screen a large number of molecules or compounds for their ability to form complexes with the p35nck5a binding protein of the invention. It also provides a method of using the p35nck5a binding protein of the invention to purify a molecule or compound which specifically binds the p35nck5a binding protein of the invention.|
|Rights: ||This patent is also available at HKUST Technology Transfer Center Patent Search at <http://patentsearch.ttc.ust.hk/ListPatentsDetail.asp?id=152>|
|Appears in Collections:||BICH Patents|
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