|
HKUST Institutional Repository >
Biochemistry >
BICH Patents >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/1783.1/3465
|
| Title: | Antisense oligonucleotides targeted to human cdc45 |
| Authors: | Liang, Chun
Feng, Dao-rong
Yu, Zhiling |
| Keywords: | Cdc6
Mcm2
Mcm
Cdc45
Cdc6 and antisense
Mcm2 and antisense
Mcm and cancer
Cdc45 and antisense
Cdc6 and cancer
Mcm2 and cancer
Cdc45 and cancer |
| Issue Date: | 1-Jul-2008 |
| Citation: | US Patent 7,393,950 B2, 2008 |
| Abstract: | Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are introduced. One aspect provides an antisense oligonucleotides that inhibits the expression of human replication-initiation protein and has a sequence complementary to at least a portion of a target sequence encoding a human replication initiation gene. By administering a therapeutically effective amount of antisense oligonucleotides or by contacting the hyperproliferating cells with an effective amount of antisense oligonucleotides, expression of replication-initiation protein is inhibited. Methods of screening and testing active antisense oligonucleotides for their ability to inhibit gene expression are also introduced. |
| Rights: | This patent is also available at HKUST Technology Transfer Center Patent Search at <http://patentsearch.ttc.ust.hk/ListPatentsDetail.asp?id=174> |
| URI: | http://hdl.handle.net/1783.1/3465 |
| Appears in Collections: | BICH Patents
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| US7393950.pdf | | 2093Kb | Adobe PDF | View/Open |
|
All items in this Repository are protected by copyright, with all rights reserved.
|
