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Title: Antisense oligonucleotides targeted to human cdc45
Authors: Liang, Chun
Feng, Dao-rong
Yu, Zhiling
Keywords: Cdc6
Cdc6 and antisense
Mcm2 and antisense
Mcm and cancer
Cdc45 and antisense
Cdc6 and cancer
Mcm2 and cancer
Cdc45 and cancer
Issue Date: 1-Jul-2008
Citation: US Patent 7,393,950 B2, 2008
Abstract: Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are introduced. One aspect provides an antisense oligonucleotides that inhibits the expression of human replication-initiation protein and has a sequence complementary to at least a portion of a target sequence encoding a human replication initiation gene. By administering a therapeutically effective amount of antisense oligonucleotides or by contacting the hyperproliferating cells with an effective amount of antisense oligonucleotides, expression of replication-initiation protein is inhibited. Methods of screening and testing active antisense oligonucleotides for their ability to inhibit gene expression are also introduced.
Rights: This patent is also available at HKUST Technology Transfer Center Patent Search at <>
Appears in Collections:BICH Patents

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