HKUST Library Institutional Repository Banner

HKUST Institutional Repository >
Biochemistry >
BICH Doctoral Theses >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/6259
Title: GABRB2 in schizophrenia and bipolar disorder : disease association, gene expression and clinical correlations
Authors: Chen, Jianhuan
Issue Date: 2009
Abstract: The schizophrenia- (SCZ-) associated GABAA receptor β2 subunit gene GABRB2 was recently reported with bipolar disorder (BPD) association in US Caucasians. The present study examined the functional mechanism of GABRB2 in the two major psychotic disorders. Association of GABRB2 with both SCZ and BPD was compared; GABRB2 expression was quantified in post-mortem brains; and clinical parameters were analyzed for genotypic correlations. Although weaker than its association with SCZ, significant association of GABRB2 with BPD was found in both German and Chinese, especially for the haplotypes rs1816071-rs187269 and rs1816072-rs187269 for which the M-M variants showed higher frequency in disease than control. Significant reduction in GABRB2 expression was shown for BPD in a genotype-dependent manner, but to a lesser extent than that reported for SCZ. Temporal effects on GABRB2 expression were observed. Moreover, for the homozygous major genotypes of rs1816071, rs1816072 and rs187269, expression increased with time in CON but decreased in SCZ and BPD. The genotypes of these three SNPs were further correlated with antipsychotics dosage in SCZ cohorts. The results highlight the importance of GABRB2 in disease etiology, with respect to haplotype association, as well as reduction of and temporal effects on gene expression in both SCZ and BPD, but to a lesser extent in the latter, supporting the suggestion that functional psychosis can be conceptualized as a continuous spectrum of clinical phenotypes rather than as distinct categories.
Description: Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2009
xvi, 120 p. : ill. (some col.) ; 30 cm
HKUST Call Number: Thesis BICH 2009 Chen
URI: http://hdl.handle.net/1783.1/6259
Appears in Collections:BICH Doctoral Theses

Files in This Item:

File Description SizeFormat
th_redirect.html0KbHTMLView/Open

All items in this Repository are protected by copyright, with all rights reserved.