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Title: A Screw-actuated pneumatic valve for portable, disposable microfluidics
Authors: Zheng, Yizhe
Dai, Wen
Wu, Hongkai
Keywords: Pneumatic valve
Microfluidic technology
Soft lithography
Issue Date: 7-Feb-2009
Citation: Lab on a chip, v. 9 no. 3, p. 469-472
Abstract: This work describes a simple and inexpensive approach for controlling the pneumatic valves that are invented in Quake’s group to miniaturize the whole system for portable and disposable microfluidic devices. The valves are assembled from two parts. One is the polydimethylsiloxane (PDMS) part that includes multilayer structures of control channels and microfluidic channels formed by multilayer soft lithography. The other is a polymethylmethacrylate (PMMA) frame for pressure control. Turning the screws into the control channel inlet (filled with water and covered with a thin PDMS membrane) actuates the valve by creating pressure in the control channel. With this PMMA frame, the valve avoids the bulky and expensive external pressure-control facilities that are used in a normal pneumatic valve without losing most merits of Quake’s valve (simple to fabricate; easy to be integrated; no dead volume; and ready to gain high density). They can also be easily integrated into portable, disposable microfluidic devices for doing various reactions.
Rights: Lab on a Chip © Royal Society of Chemistry 2009. The final published article is available at
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