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Title: Preliminary study of detecting neoplastic growths in vivo with real time calibrated autofluorescence imaging
Authors: Wu, Tao
Qu, Jianan
Cheung, Tak-Hong
Lo, Keith Wing-Kit
Yu, Mei-Yung
Keywords: Neoplastic growths
In vivo
Real time
Autofluorescence imaging
Issue Date: 2003
Citation: Optics express, v. 11, no. 4, Feb. 2003, p. 291-298
Abstract: The goal of this study was to evaluate the capabilities of a calibrated autofluorescence imaging method for detecting neoplastic lesions. An imaging system that records autofluorescence images calibrated by the cross-polarized reflection images from excitation was instrumented for the evaluation. Cervical tissue was selected as the living tissue model. Sixteen human subjects were examined in vivo with the imaging system before routine examination procedures. It was found that calibrated autofluorescence signals from neoplastic lesions were generally lower than signals from normal cervical tissue. Neoplastic lesions can be differentiated from surrounding normal tissue based on the contrast in the calibrated autofluorescence. The effects of the optical properties of tissue on the calibrated fluorescence imaging were investigated.
Rights: We would like to give credit to the Optical Society of America for granting us permission to repost this Optics Express article. The original article is posted on the journal's web site at
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