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Title: Wide dynamic range front-end amplifier for cell recording with microelectrode arrays
Authors: Guo, Jing
Liu, Bing
Yuan, Jie
Keywords: CMOS integrated circuits
Bioelectric potentials
Biomedical electronics
Cellular biophysics
Issue Date: Nov-2009
Citation: Proceedings 2009 IEEE Biomedical Circuits and Systems Conference, BioCAS 2009, 26-28 November 2009, Beijing, China, p. 65-68
Abstract: In a cell recording system, characteristics of the cell and microelectrode array (MEA) interface impose challenging requirements on the design of front-end amplifier with regard to input-referred noise, linearity, dynamic range (DR), input impedance, pitch size and differential electrode offset (DEO) cancellation. Previous front-end amplifier designs for cell recording demonstrated 2~7μVrms input referred noise and about 1% total harmonic distortion (THD) for dozens of mVpp input signal, which corresponds to about 60dB DR. However, front-end with wider DR is needed for many new cellular applications. This paper reports the design of a new wide DR front-end amplifier which uses chopping to suppress the noise, and a new current feedback scheme to improve the linearity. The new design is implemented in a 0.35μm CMOS process. SPICE simulation shows that the new amplifier achieves THD lower than -70dB with 20mVpp input signal and 0.75μVrms inputreferred noise. For local field potentials (<200Hz), the DR extends to 80dB. The new amplifier has more than 0.62GΩ input impedance at 20 kHz and consumes 20μW power.
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