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Title: A point-of-care immunotest for bedside determination of heart-type fatty acid-binding protein
Authors: Tong, Chao-Yang
Chan, Cangel Pui Yee
Cheung, Kwan-yee
Cautherley, George W. H.
Glatz, Jan F. C.
Renneberg, Reinhard
Keywords: Acute myocardial infarction
Cardiac troponin T
Creatine kinase MB
Heart-type fatty acid-binding protein
Issue Date: Mar-2010
Citation: Analytical letters, v. 43, iss. 4, p. 735-744
Abstract: Ninety-one patients presenting to the Emergency Department suspected of acute myocardial infarction (AMI) with a median symptom onset of 6 h, of which 75 had AMI. A point-of-care immunotest for heart-type fatty acid-binding protein (H-FABP) was found to have a significant better sensitivity than the other markers and a better specificity than myoglobin and creatinine kinase MB. H-FABP gave the greatest area under the receiver operating characteristic curve (0.864) for those admitted within 6 h. H-FABP was also found to be the most efficient marker to diagnose patients suspected of AMI without ST-elevation and with a negative cardiac troponin T.
Rights: This is a preprint of an article whose final and definitive form has been published in the Analytical Letters c 2010 copyright Taylor & Francis; Analytical Letters is available online at:
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