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Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/6883
Title: Biofunctional magnetic nanoparticles for pathogen detection
Authors: Xu, Bing
Ho, Pak Leung
Gu, Hongwei
Keywords: Bacteria detection
Magnetic nanoparticles
Pathogen detection
Issue Date: 13-Jul-2010
Citation: US Patent 7,754,444 B2, 2010
Abstract: This invention provides a method of detecting pathogens comprising the steps of: (a) contacting a sufficient amount of biofunctional magnetic nanoparticles with an appropriate sample for an appropriate period of time to permit the formation of complexes between the pathogens in the sample and the nanoparticles; (b) using a magnetic field to aggregate said complexes; and (c) detecting said complexes. The method may further comprise the additional step of removing said complexes. The biofunctional magnetic nanoparticles are preferably a conjugate of vancomycin and FePt. The pathogens may be bacteria or viruses, and the sample may be a solid, liquid, or gas. Detection may involve conventional fluorescence assay, enzyme-linked immunosorbent assay (ELISA), optical microscope, electron microscope, or a combination thereof. The sensitivity of detection for the method is at least as low as 10 colony forming units (cfu) of the pathogens in one milliliter of solution within one hour.
Rights: This patent is also available at HKUST Technology Transfer Center Patent Search at <http://patentsearch.ttc.ust.hk/ListPatentsDetail.asp?id=302>
URI: http://hdl.handle.net/1783.1/6883
Appears in Collections:MECH Patents

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