HKUST Institutional Repository >
BIOL Conference Papers >
Please use this identifier to cite or link to this item:
|Title: ||Regulation of G2/M cell cycle DNA damage checkpoints|
|Authors: ||Arooz, Talha M.|
Chan, Ho Yee
Lau, Anita W. S.
Leung, Ka Man
Po, Lai See
Siu, Wai Yi
Tsang, Fan Cheung
Poon, Randy Y. C.
|Keywords: ||Cell cycle checkpoints|
G2/M DNA damage checkpoint
|Issue Date: ||2001 |
|Citation: ||Proceedings advanced study institute on molecular genetic basis of cancer, Hong Kong, 6-12 Jan. 2001, HKUST, Hong Kong, 2001, p. 230-243|
|Abstract: ||Deregulation of the cell cycle checkpoints is a key step in tumorigenesis. we present evidence that apart from CDC25, WEE1 may also be important for the G2/M DNA damage checkpoints. ING1 is a candidate tumor suppressor that cooperates with p53 to inhibit cell proliferation. We show that ING1 can regulate the cell cycle and the DNA damage responses at G2/M phase independent of p53 functions. ING1b enhanced the p53-independent G2/M DNA damage checkpoint induced by adriamycin, but did not affect the G1 DNA damage checkpoint. No significant transactivation of p21CIP1/WAF1 and MDM2 by ING1 in the absence of p53 was observed, suggesting that mechanisms involving activation of p53-related proteins are unlikely to contribute to the G2/M cell cycle arrest caused by ING1b. These data provide evidence of the involvement of WEE1 and ING1 in the G2/M DNA damage checkpoint. Understanding precisely how these proteins regulate the cell cycle and checkpoints may shed light on the mechanism of tumorigenesis.|
|Appears in Collections:||BIOL Conference Papers|
Files in This Item:
All items in this Repository are protected by copyright, with all rights reserved.