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Elucidation of the c-Jun N-terminal kinase pathway mediated by Epstein-Barr virus-encoded latent membrane protein

Authors Wan, Jun View this author's profile
Sun, Luguo HKUST affiliated (currently or previously)
Mendoza, Jennifer Woo
Chui, Yiuloon
Huang, Dolly
Chen, Zhijian
Suzuki, Nobutaka
Suzuki, Shinobu
Yeh, Wenchen
Akira, Shizuo
Matsumoto, Kunihiro
Liu, Zhenggang
Wu, Zhenguo View this author's profile
Issue Date 2004
Source Molecular and cellular biology , v. 24, (1), 2004, JAN, p. 192-199
Summary Epstein-Barr virus (EBV) is associated with several human diseases including infectious mononucleosis and nasopharyngeal carcinoma. EBV-encoded latent membrane protein 1 (LMP1) is oncogenic and indispensable for cellular transformation caused by EBV. Expression of LMP1 in host cells constitutively activates both the c-Jun N-terminal kinase (JNK) and NF-kappaB pathways, which contributes to the oncogenic effect of LMP1. However, the underlying signaling mechanisms are not very well understood. Based mainly on overexpression studies with various dominant-negative constructs, LMP1 was generally thought to functionally mimic members of the tumor necrosis factor (TNF) receptor superfamily in signaling. In contrast to the prevailing paradigm, using embryonic fibroblasts from different knockout mice and the small interfering RNA technique, we find that the LMP1-mediated JNK pathway is distinct from those mediated by either TNF-alpha or interleukin-1. Moreover, we have further elucidated the LMP1-mediated JNK pathway by demonstrating that LMP1 selectively utilizes TNF receptor-associated factor 6, TAK1/TAB1, and c-Jun N-terminal kinase kinases 1 and 2 to activate JNK.
ISSN 0270-7306
Rights Copyright © American Society for Microbiology [Molecular and Cellular Biology, v. 24, no. 1, Jan. 2004, p. 192-199]
Language English
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