Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/1433

Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family

Authors Morita, K
Chow, KL
Ueno, N
Issue Date 1999
Source Development, v. 126, (6), 1999, MAR, p. 1337-1347
Summary We have identified a new member of the TGF-beta superfamily, CET-1, from Caenorhabditis elegans, which is expressed in the ventral nerve cord and other neurons, cet-1 null mutants have shortened bodies and male tail abnormal phenotype resembling sma mutants, suggesting cet-1, sma-2, sma-3 and sma-l share a common pathway. Overexpression experiments demonstrated that cet-1 function requires wild-type srna genes, Interestingly, CET-1 appears to affect body length in a dose-dependent manner. Heterozygotes for cet-1 displayed body lengths ranging between null mutant and wild type, and overexpression of CET-1 in wild-type worms elongated body length close to ion mutants. In male sensory ray patterning, lack of cet-1 function results in ray fusions, Epistasis analysis revealed that mab-21 lies downstream and is negatively regulated by the cet-1/sma pathway in the male tail. Our results show that cet-1 controls diverse biological processes during C. elegans development probably through different target genes.
Subjects
ISSN 0950-1991
Rights Permission is granted by the Company of Biologists Ltd. The paper was published in Development 1999 126 : 1337-1347.
Language English
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