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Synthesis & application of biofunctional nanostructures

Synthesis and application of biofunctional nanostructures

Authors Gu, Hongwei
Issue Date 2004
Summary Based on the synthesis of monodispersed metal containing nanoparticles, we developed a series of surface/organic chemistry to explore the applications of biofunctional nanoparticles, including the synthesis of vancomycin (Van)-capped Au or FePt nanoparticles (Au@Van or FePt@Van). The in vitro antibacterial activities of Au@Van demonstrate that nanoparticles are ideal platforms for polyvalent interactions, which are responsible for FePt@Van capturing vancomycin resistant enterococci (VRE), E. coli, and other Gram-positive bacteria at ultra-low concentration (~101 cfu/mL). After conjugated to biotin, the FePt@Biotin nanoparticles can be used to concentrate streptavidin with the high efficiency at 0.8 pM. We also developed several chemical methods to create sophisticated nanostructures, including the synthesis of high Kμ magnetic nanoparticles (FePt, SmCo5) with different sizes and shapes, the production of ambient stable nanoparticles (e.g., SmCo5@Fe2O3), and the formation of asymmetric nanostructures (e.g., heterodimers of FePt-CdS or M-Ag; nanosponges of FePt-ZnS).
Note Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2004
Language English
Format Thesis
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