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Calcium signalling during zebrafish embryonic development

Authors Webb, SE
Miller, AL
Issue Date 2000
Source BioEssays , v. 22, (2), 2000, FEB, p. 113-123
Summary Calcium signals appear throughout the first 24 hours of zebrafish development. These begin at egg activation, then continue to be generated throughout the subsequent zygote, cleavage, blastula, gastrula, and segmentation periods. They are thus associated with the major phases of pattern formation: cell proliferation, cell differentiation, axis determination, the generation of primary germ layers, the emergence of rudimentary organ systems, and therefore the establishment of the basic vertebrate body plan. When signals need to be transmitted across significant distances they take the form of waves, either intracellular waves when the cell size is large, or later in development when the cell size is reduced, intercellular waves. We will consider both types of calcium signals and their integration into signalling networks, and discuss their possible functions and developmental significance with regard to pattern formation. (C) 2000 John Wiley & Sons, Inc.
ISSN 0265-9247
Rights Permission is granted by the Company of Biologists Ltd. The paper was published in BioEssays, vol. 22, iss. 2, February 2000, p. 113-123.
Language English
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