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Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution, and receptor specificity

Authors Ip, N.Y. View this author's profile
Ibanez, C.F.
Nye, S.H.
McClain, J.
Jones, P.F.
Gies, D.R.
Belluscio, L.
Le Beau, M.M.
Espinosa III, R.
Squinto, S.P.
Persson, H.
Yancopoulos, G.D.
Issue Date 1992
Source Proceedings of the National Academy of Sciences of the United States of America , v. 89, (7), 1992, p. 3060-3064
Summary Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT- 4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4.
ISSN 0027-8424
Language English
Format Article
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