Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/32755

Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF

Authors Lohof, A.M.
Ip, N.Y. View this author's profile
Poo, M.
Issue Date 1993
Source Nature , v. 363, (6427), 1993, p. 350-353
Summary The neurotrophins are a family of neurotrophic factors that promote survival and differentiation of various neuronal populations. Although the long-term effects of neurotrophins on neuronal survival and differentiation have heen intensively studied, nothing is known about their effects on synaptic function. Here we report that acute exposure to neurotrophin-3 (NT-3) or brain-derived neurotrophic factor (BDNF), but not nerve growth factor (NGF), rapidly potentiates the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture. The effect appears to be presynaptic in origin and to be mediated by the Trk family of receptor tyrosine kinases. These results provide evidence for the regulation of the function of developing synapses by neurotrophins.
ISSN 0028-0836
Language English
Format Article
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