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Neurotrophin-3: A neurotrophic factor related to NGF and BDNF

Authors Maisonpierre, P.C.
Belluscio, L.
Squinto, S.
Ip, N.Y. View this author's profile
Furth, M.E.
Lindsay, R.M.
Yancopoulos, G.D.
Issue Date 1990
Source Science , v. 247, (4949 I), 1990, p. 1446-1451
Summary The development and maintenance of the nervous system depends on proteins known as neurotrophic factors. Although the prototypical neurotrophic factor, nerve growth factor (NGF), has been intensively studied for decades, the discovery and characterization of additional such factors has been impeded by their low abundance. Sequence homologies between NGF and the recently cloned brain-derived neurotrophic factor (BDNF) were used to design a strategy that has now resulted in ithe cloning of a gene encoding a novel neutrophic factor, termed neurotrophin-3 (NT-3). The distribution of NT-3 messenger RNA and its biological activity on a variety of neuronal populations clearly distinguish NT-3 from NGF and BDNF, and provide compelling evidence that NT-3 is an authentic neurotrophic factor that has its own characteristic role in vivo.
ISSN 0036-8075
Language English
Format Article
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