Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/3378

p35<sup>nck5a</sup> binding proteins

Authors Ching, Yick Pang
Wang, Jerry H. C.
Issue Date 2004-06-22
Source US Patent , 6,753,413 B1, 2004
Summary Cyclin-dependent protein kinase 5 (Cdk5) has been shown to be involved in neuronal cell differentiation in the form of an active kinase, named neuronal Cdc2-like kinase (Nclk). However, its activity was shown to be suppressed by forming complex with p35<sup>nck5a</sup>. Therefore, there is a need for identifying the identities of various binding proteins in the macromolecular protein complex. The present inventors have now succeeded in isolating three novel p35<sup>nck5a</sup> binding proteins useful for a variety of purposes, particularly as tools to analyze how p35<sup>nck5a</sup> interacts with other proteins and for drug development for Alzheimer's Disease. This invention provides a method to screen a large number of molecules or compounds for their ability to form complexes with the p35<sup>nck5a</sup> binding protein of the invention. It also provides a method of using the p35<sup>nck5a</sup> binding protein of the invention to purify a molecule or compound which specifically binds the p35<sup>nck5a</sup> binding protein of the invention.
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Language English
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