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DNA sequence encoding a retinoic acid regulated protein

Authors Ip, Nancy Y.
Cheung, William M. W.
Issue Date 2007-10-02
Source US Patent, 7,276,595 B2, 2007
Summary Retinoic acid (RA) induces the differentiation of many cell types such as epithelial cells and cancer cells. Clinically, RA has been demonstrated to be efficacious in the treatment of promyelocytic leukemia, a type of blood disease. RA has also been shown to affect patterning and neurogenesis in vivo. Since the discovery of the RA receptors that transduce RA signals, one major thrust has been to identify RA-responsive genes to elucidate the molecular mechanisms by which RA involved in different physiological activities. A novel cDNA sequence (Sequence 8.31) that is down-regulated during the RA-induced neuronal differentiation is identified. The gene encoded by this sequence might play a role in maintaining the embryonic identity of the neuronal precursor cells, the functioning of the placenta as well as the later physiological functions of the skeletal muscles. Since RA is used as therapeutic agents for leukemia, this invention allows development of better approaches for the treatment of cancer cells. Moreover, the cloning of genes involved in RA-induced neuronal differentiation allows development of new therapeutic approaches for the treatment of neurodisorders.
Language English
Format Patent
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