Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/3465

Antisense oligonucleotides targeted to human cdc45

Authors Liang, Chun
Feng, Dao-rong
Yu, Zhiling
Issue Date 2008-07-01
Source US Patent , 7,393,950 B2, 2008
Summary Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are introduced. One aspect provides an antisense oligonucleotides that inhibits the expression of human replication-initiation protein and has a sequence complementary to at least a portion of a target sequence encoding a human replication initiation gene. By administering a therapeutically effective amount of antisense oligonucleotides or by contacting the hyperproliferating cells with an effective amount of antisense oligonucleotides, expression of replication-initiation protein is inhibited. Methods of screening and testing active antisense oligonucleotides for their ability to inhibit gene expression are also introduced.
Subjects
Mcm
Rights This patent is also available at HKUST Technology Transfer Center Patent Search at <http://patentsearch.ttc.ust.hk/ListPatentsDetail.asp?id=174>
Language English
Format Patent
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