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Antisense oligonucleotides targeted to human cdc45

Authors Liang, Chun View this author's profile
Feng, Dao-rong
Yu, Zhiling HKUST affiliated (currently or previously)
Issue Date 2008-07-01
Source US Patent , 7,393,950 B2, 2008
Summary Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are introduced. One aspect provides an antisense oligonucleotides that inhibits the expression of human replication-initiation protein and has a sequence complementary to at least a portion of a target sequence encoding a human replication initiation gene. By administering a therapeutically effective amount of antisense oligonucleotides or by contacting the hyperproliferating cells with an effective amount of antisense oligonucleotides, expression of replication-initiation protein is inhibited. Methods of screening and testing active antisense oligonucleotides for their ability to inhibit gene expression are also introduced.
Language English
Format Patent
Access View details of TTC.PA.157 via HKUST Technology Transfer Center
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