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The involvement of JAK2/STAT2/STAT3 in myogenic differentiation

Authors Wang, Kepeng
Issue Date 2008
Summary Skeletal muscle satellite cell-derived myoblasts are mainly responsible for postnatal muscle growth and injury-induced regeneration. However, the cellular signaling pathways that control proliferation and differentiation of myoblasts remain poorly defined. Recently, we found that JAK1/STAT1/STAT3 not only participate in myoblast proliferation but also actively prevent them from premature differentiation. Unexpectedly, we found that a related pathway consisting of JAK2, STAT2, and STAT3 is required for early myogenic differentiation. Interference of this pathway by either a small molecule inhibitor or siRNA inhibits myogenic differentiation. Consistently, all three molecules are activated upon differentiation. The pro-differentiation effect of JAK2/STAT2/STAT3 is partially mediated by MyoD and MEF2. Interestingly, the expression of IGF2 gene and HGF gene is also regulated by JAK2/STAT2/STAT3, suggesting that this pathway could promote differentiation by regulating molecules known to be involved in myogenic differentiation. In summary, our current study reveals a novel role for the JAK2/STAT2/STAT3 pathway in myogenic differentiation.
Note Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2008
Language English
Format Thesis
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