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Use of marine fungus originated compounds as antifouling agents

Authors Qian, Peiyuan
Li, Xiancui
Kwong, Fuk Ning
Yang, Lai Hung
Dobretsov, Serguei Vladimirovich
Issue Date 2008-08-06
Source 中國專利, ZL 200510137017.2
Summary Although experimentation on antifouling technologies for shipping has continued for approximately 100 years, metal containing antifouling paints continue to be widely adopted. These paints are usually copper or tin based compounds like tributyl tin (TBT) that can prevent fouling by continuously releasing the copper or tin into the surrounding seawater. However, these compounds have negative effects on the marine environment. The present invention concerns alternative antifouling agents derived from marine microbes. It is based on the discovery that 3 strains of marine fungi and a deep-sea bacterium produce small molecular organic compounds that have antibacterial activity as well as inhibitory activity on larval attachment and metamorphosis of barnacle and polychaete. On contrary to majority of the currently employed biocides, the antifouling effect of these new compounds is of low-toxicity and bio-degradability. Unlike other natural products with antifouling properties derived from marine organisms, the present microbial secondary metabolites can be generated biotechnologically in large scale utilizing commercially available fermenting technology. This new invention does not require the maintenance of a marine culture for large-scale production of antifouling agents, thus resolving manufacturing problems with geographical restrictions. 海洋微生物發酵產生抗生物污損(抗菌和/或抗幼蟲附着)化合物。所產生的活性化合物為3-氯-2,5-二羥基苯甲醇,3-芐基-六氫吡咯 [1,2-a] 並吡嗪-1,4-二酮,3-甲基-N-(2-苯乙基)-丁酰胺和琥珀酸。這些化合物為無毒或低毒無重金屬物質。這些活性化合物可以單獨或組合用於產生對環境無害的抗污損涂料活性成分。
Language English
Format Patent
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