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Ca2+ signaling during embryonic cytokinesis in animal systems

Authors Webb, Sarah Elizabeth View this author's profile
Miller, Andrew Leitch View this author's profile
Issue Date 2007
Source New Comprehensive Biochemistry , / Edited by Joachim Krebs, Marek Michalak. Amsterdam : Elsevier, 2007, p. 445-470
Summary In this chapter, we provide a review of the literature that describes the role of Ca2+ signaling during embryonic cytokinesis in animal systems. We begin with a historic overview (starting with the earliest reports published in the latter part of the nineteenth century) that gives some of the first descriptions linking Ca2+ with cell division in embryos. This introductory overview also outlines the different techniques that were used and developed over time, from the pre-Ca2+ imaging days through to the sophisticated approaches that are available today for directly visualizing Ca2+ signals in living cells. In the remainder of the chapter, we describe the more recent advances in cytokinetic Ca2+-signaling research, starting where the introduction finished, in the 1990s. Reports of the various Ca2+ signals visualized during cytokinesis in fish, amphibian, echinoderm, and insect embryos using both fluorescent and luminescent Ca2+ probes are described, as well as the investigations carried out to determine both the requirement of elevated Ca2+ during cytokinesis and the source of the Ca2+ involved in this process. The current hypotheses regarding the possible roles and targets of the different cytokinetic Ca2+ signals observed are also briefly discussed. © 2007 Elsevier B.V. All rights reserved.
ISSN 0167-7306
ISBN 0444528059
Rights 'New comprehensive biochemistry © copyright 2007 Elsevier. The Journal's web site is located at
Language English
Format Book chapter
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