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Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles

Authors Xu, Chenjie
Xu, Keming HKUST affiliated (currently or previously)
Gu, Hongwei
Zheng, Rongkun
Liu, Hui
Zhang, Xixiang HKUST affiliated (currently or previously)
Guo, Zhihong View this author's profile
Xu, Bing HKUST affiliated (currently or previously)
Issue Date 2004
Source Journal of the American Chemical Society , v. 126, (32), 2004, AUG 18, p. 9938-9939
Summary We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide. Copyright © 2004 American Chemical Society.
ISSN 0002-7863
Language English
Format Article
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