Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/52604

Numerical simulation on freeze drying with dielectric material assisted microwave heating

Authors Wang, Wei HKUST affiliated (currently or previously)
Xu, Ying-mei
Ma, Hong-xin
Chen, Guo-hua View this author's profile
Issue Date 2012
Source 高校化学工程学报 , v. 26, (4), 2012, p. 575-580
Summary The effects of the dielectric material on the microwave freeze-drying process were theoretically studied by mathematically solving the heat and mass transfer model considering the hygroscopic effect with a moving boundary in the porous media. Sintered silicon carbide (SiC) was used as the dielectric material, and the mannitol, a typical pharmaceutical excipient, was selected as the solute in aqueous solution. Simulation results show that the dielectric material can significantly enhance the microwave freeze drying rate under the experimental operating conditions, especially when the solid content in the freeze dried solution is very low or the solid product has a very small dielectric loss factor. Comparisons of the drying curves display good agreements between experimental measurements and model predictions. Based on the profiles of ice saturation and temperature, mechanisms of heat and mass transfer inside the material were analyzed, and the drying rate-controlling factor was discussed.
Subjects
ISSN 1003-9015
Language English
Format Article
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