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Ultrasound Bio-Microscopic Image Segmentation for Evaluation of Zebrafish Cardiac Function

Authors Zhou, Xiaowei HKUST affiliated (currently or previously).
Sun, Lei
Yu, Yanyan
Qiu, Weibao
Lien, Ching-Ling
Shung, K. Kirk
Yu, Weichuan View this author's profile
Issue Date 2013
Source IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control , v. 60, (4), 2013, article number 6489806, p. 718-726
Summary Zebrafish can fully regenerate their myocardium after ventricular resection without evidence of scars. This extraordinary regenerative ability provides an excellent model system to study the activation of the regenerative potential for human heart tissue. In addition to the morphology, it is vital to understand the cardiac function of zebrafish. To characterize adult zebrafish cardiac function, an ultrasound biomicroscope (UBM) was customized for real-time imaging of the zebrafish heart (about 1 mm in diameter) at a resolution of around 37 mu m. Moreover, we developed an image segmentation algorithm to track the cardiac boundary and measure the dynamic size of the zebrafish heart for further quantification of zebrafish cardiac function. The effectiveness and accuracy of the proposed segmentation algorithm were verified on a tissue-mimicking phantom and in vivo zebrafish echocardiography. The quantitative evaluation demonstrated that the accuracy of the proposed algorithm is comparable to the manual delineation by experts.
ISSN 0885-3010
Language English
Format Article
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