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Using microPET imaging in quantitative verification of the acupuncture effect in ischemia stroke treatment

Authors Liu, Huafeng HKUST affiliated (currently or previously)
Shen, Xiaoyan
Tang, Hongtu
Li, Jia
Xiang, Ting
Yu, Weichuan View this author's profile
Issue Date 2013
Source Scientific Reports , v. 3, 2013, article number 1070
Summary Acupuncture has been indispensable in Chinese medicine. However, its function still remains elusive. This paper studies the effect of acupuncture in ischemia stroke treatment using the Sprague Dawley rat animal model. We induced focal cerebral ischemia in rats using the middle cerebral artery occlusion (MCAO) procedure. For each rat in the real acupuncture group (n = 63), the sham acupoint treatment group (n = 62), and the blank control group (n = 30), we acquired 3-D fluorodeoxyglucose-microPET images at baseline, after MCAO, and after treatment, respectively. Then, we measured the changes of the injury-volume in the right hemisphere of these rats. The measurements showed that real acupuncture slightly reduced the injury-volume, sham acupoint treatment increased the injury-volume, and blank control had no obvious effect in reducing the injury-volume. Statistical tests also confirmed that acupuncture was more effective than random stimulus in improving the metabolic recovery after stroke.
ISSN 2045-2322
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Language English
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