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Issues in Freeze Drying of Aqueous Solutions

Authors Wang, Wei HKUST affiliated (currently or previously)
Chen, Mo
Chen, Guohua View this author's profile
Issue Date 2012
Source Chinese Journal of Chemical Engineering , v. 20, (3), June 2012, p. 551-559
Summary Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry. The increased importance of the process is gaining a worldwide interest of research. A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error empiricism. Formulation and process development need a systematical understanding of the physical chemistry of freezing and freeze drying, material science and mechanisms of heat and mass transfer. This paper presents an overview on freeze drying of aqueous solutions based on publications in the past few decades. The important issues of the process are analyzed.
ISSN 1004-9541
Language English
Format Article
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