Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery
Qi, Robert Z.
|Source||Topics in Current Chemistry , v. 331, 2013, p. 193-210|
|Summary||In this chapter we first describe the applications of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) in biomarker discovery. After a summary of the general analysis pipeline of MALDI MS data, each step of the pipeline will be elaborated in detail. In particular we try to provide a categorization of existing solutions with the hope that the reader can obtain a global picture on this topic. In addition we show how to apply such an analysis pipeline in protein and glycan profiling for biomarker discovery and for a deeper understanding of diseases. Finally we discuss the limitations of current analysis methods and the perspectives of future research.|
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