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Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery

Authors He, Zengyou HKUST affiliated (currently or previously)
Qi, Robert Z. View this author's profile
Yu, Weichuan View this author's profile
Issue Date 2013
Source Topics in Current Chemistry , v. 331, 2013, p. 193-210
Summary In this chapter we first describe the applications of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) in biomarker discovery. After a summary of the general analysis pipeline of MALDI MS data, each step of the pipeline will be elaborated in detail. In particular we try to provide a categorization of existing solutions with the hope that the reader can obtain a global picture on this topic. In addition we show how to apply such an analysis pipeline in protein and glycan profiling for biomarker discovery and for a deeper understanding of diseases. Finally we discuss the limitations of current analysis methods and the perspectives of future research.
ISSN 0340-1022
ISBN 978-3-642-35665-0
Language English
Format Article
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