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Achieving new developments in DNA nanotechnology by means of DNA self-assembly

Authors Cheng, Jie
Issue Date 2008
Summary In this work, we describe the new developments in DNA nanotechnology that we have achieved by means of DNA self‐assembly. We have designed and developed a novel DNA‐induced solution‐hydrogel transition system to reversibly capture and release proteins. This may provide a promising and potentially convenient tool in drug delivery and protein detection by biosensors. We have also demonstrated a method of patterning the 1D and 2D arrays of gold nanoparticles (NPs) on DNA self‐assembled scaffolds. 5 nm gold NPs were accurately positioned at the center of each 4×4 tile motif of the DNA scaffold, resulting in 1D or 2D patterns of gold NPs. This precise, controllable scaffolding technology may become a promising tool for nano‐scaled fabrication of electronics and photonic devices. In addition to gold NPs, we have also fabricated three types of magnetic NPs: FePt NPs, FeAu NPs, and Fe3O4@Au core‐shell NPs. In our future work, we will try to combine these magnetic NPs with DNA nano‐patterning to obtain a nano‐magnetic supermatrix, which may offer potential applications in information storage and microelectronics.
Note Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2008
Language English
Format Thesis
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