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Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma

Authors Li, Jinquan
Li, Li
Chen, Hanqing
Chang, Qing HKUST affiliated (currently or previously)
Liu, Xudong
Wu, Yang
Wei, Chenxi
Li, Rui
Kwan, Joseph Kai Cho View this author's profile
Yeung, King Lun View this author's profile
Xi, Zhuge
Lu, Zhisong
Yang, Xu
Issue Date 2014
Source Scientific Reports , v. 4, March 2014, article number 4275
Summary The aggravating effects of zero-dimensional, particle-shaped nanomaterials on allergic asthma have been previously investigated, but similar possible effects of one-dimensional shaped nanomaterials have not been reported. More importantly, there are no available means to counteract the adverse nanomaterial effects to allow for their safe use. In this study, an ovalbumin (OVA)-sensitized rat asthma model was established to investigate whether single walled carbon nanotubes (SWCNTs) aggravate allergic asthma. The results showed that SWCNTs in rats exacerbated OVA-induced allergic asthma and that this exacerbation was counteracted by concurrent administration vitamin E. A mechanism involving the elimination of reactive oxygen species, downregulation of Th2 responses, reduced Ig production, and the relief of allergic asthma symptoms was proposed to explain the antagonistic effects of vitamin E. This work could provide a universal strategy to effectively protect people with allergic asthma from SWCNTs or similar nanomaterial-induced aggravating effects.
ISSN 2045-2322
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Language English
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