Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/6454

Generation of alginate microfibers with a roller-assisted microfluidic system

Authors Su, Jing
Zheng, Yizhe
Wu, Hongkai
Issue Date 2009
Source Lab on a chip , v. 9, (7), 2009, p. 996-1001
Summary This work describes a convenient microfluidic strategy with a simple and minimal-requirement design for the generation of uniformly-sized alginate gel fibers with diameters one order of magnitude smaller than those formed in conventional methods. Different from common microfluidic methods, our system contains a single microchannel through which alginate solutions are transported and squeezed into a calcium chloride solution. Ca2+ ions immediately cross link the alginate solution into a gel state that is collected with a rotor. We use microchannels to define the initial size of the alginate fibers and a roller to further reduce the fiber size (diameter) by one order of magnitude down to similar to 1 mu m. The size of the formed fibers can be well controlled by adjusting the corresponding parameters, and be predicted with a simple equation. In addition, various functional materials (colloidal particles, bacteria and nanoparticles) have been encapsulated into the gel fibers with this technique.
Subjects
ISSN 1473-0197
Rights Lab on a Chip © Royal Society of Chemistry 2009. The final published article is available at http://library.ust.hk/cgi/db/doi.pl?10.1039/b813518e
Language English
Format Article
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