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Preliminary study of detecting neoplastic growths in vivo with real time calibrated autofluorescence imaging

Authors Wu, Tao HKUST affiliated (currently or previously)
Qu, Jianan Y. View this author's profile
Cheung, Tak-Hong
Lo, Keith Wing-Kit
Yu, Mei-Yung
Issue Date 2003
Source Optics express , v. 11, (4), 2003, p. 291-298
Summary The goal of this study was to evaluate the capabilities of a calibrated autofluorescence imaging method for detecting neoplastic lesions. An imaging system that records autofluorescence images calibrated by the cross-polarized reflection images from excitation was instrumented for the evaluation. Cervical tissue was selected as the living tissue model. Sixteen human subjects were examined in vivo with the imaging system before routine examination procedures. It was found that calibrated autofluorescence signals from neoplastic lesions were generally lower than signals from normal cervical tissue. Neoplastic lesions can be differentiated from surrounding normal tissue based on the contrast in the calibrated autofluorescence. The effects of the optical properties of tissue on the calibrated fluorescence imaging were investigated. (C) 2003 Optical Society of America.
ISSN 1094-4087
Rights We would like to give credit to the Optical Society of America for granting us permission to repost this Optics Express article. The original article is posted on the journal's web site at
Language English
Format Article
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