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Wide Dynamic Range Front-end Amplifier for Cell Recording with Microelectrode Arrays

Authors Guo, Jing
Liu, Bing
Yuan, Jie View this author's profile
Issue Date 2009
Source 2009 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS 2009) , 26-28 November 2009, p. 65-68
Summary In a cell recording system, characteristics of the cell and microelectrode array (MEA) interface impose challenging requirements on the design of front-end amplifier with regard to input-referred noise, linearity, dynamic range (DR), input impedance, pitch size and differential electrode offset (DEO) cancellation. Previous front-end amplifier designs for cell recording demonstrated 2 similar to 7 mu V(rms), input referred noise and about 1% total harmonic distortion (THD) for dozens of mV(pp) input signal, which corresponds to about 60dB DR. However, front-end with wider DR is needed for many new cellular applications. This paper reports the design of a new wide DR front-end amplifier which uses chopping to suppress the noise, and a new current feedback scheme to improve the linearity. The new design is implemented in a 0.35 mu m CMOS process. SPICE simulation shows that the new amplifier achieves THD lower than -70dB with 20mV(pp) input signal and 0.75 mu V(rms) input-referred noise. For local field potentials (< 200Hz), the DR extends to 80dB. The new amplifier has more than 0.62G Omega input impedance at 20 kHz and consumes 2011W power.
ISBN 978-1-4244-4917-0
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Language English
Format Conference paper
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