Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/6693

Wide Dynamic Range Front-end Amplifier for Cell Recording with Microelectrode Arrays

Authors Guo, Jing
Liu, Bing
Yuan, Jie
Issue Date 2009
Source 2009 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS 2009) , 26-28 November 2009, p. 65-68
Summary In a cell recording system, characteristics of the cell and microelectrode array (MEA) interface impose challenging requirements on the design of front-end amplifier with regard to input-referred noise, linearity, dynamic range (DR), input impedance, pitch size and differential electrode offset (DEO) cancellation. Previous front-end amplifier designs for cell recording demonstrated 2 similar to 7 mu V(rms), input referred noise and about 1% total harmonic distortion (THD) for dozens of mV(pp) input signal, which corresponds to about 60dB DR. However, front-end with wider DR is needed for many new cellular applications. This paper reports the design of a new wide DR front-end amplifier which uses chopping to suppress the noise, and a new current feedback scheme to improve the linearity. The new design is implemented in a 0.35 mu m CMOS process. SPICE simulation shows that the new amplifier achieves THD lower than -70dB with 20mV(pp) input signal and 0.75 mu V(rms) input-referred noise. For local field potentials (< 200Hz), the DR extends to 80dB. The new amplifier has more than 0.62G Omega input impedance at 20 kHz and consumes 2011W power.
Subjects
ISBN 978-1-4244-4917-0
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Language English
Format Conference paper
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