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Detection of serum neopterin for early assessment of dengue virus infection

Authors Chan, Cangel P.Y. HKUST affiliated (currently or previously)
Choi, Junet W.Y.
Cao, Kai-Yuan
Wang, Ming
Gao, Yang
Zhou, Duan-Hua
Di, Biao
Xu, Hui-Fang
Leung, Man-Fai HKUST affiliated (currently or previously)
Bergmann, Andreas
Lehmann, Matthias
Nie, Yong-Mei
Cautherley, George W.H.
Fuchs, Dietmar
Renneberg, Reinhard View this author's profile
Zheng, Bo-Jian
Issue Date 2006
Source JOURNAL OF INFECTION , v. 53, (3), 2006, SEP, p. 152-158
Summary Objective: Neopterin is generated and released in increased amounts by macrophages upon activation by interferon-gamma during Th1-type immune response. The potential usefulness of neopterin in early prognostic information of dengue virus infection was investigated. Methods: Neopterin concentrations were determined in serum samples from 110 dengue fever (DF) patients. The neopterin levels were compared with those in 50 measles and 40 influenza patients; 155 healthy blood donors served as controls. Results: In acute sera of DF patients mean neopterin concentration was 48.2 nmol/ L, which was higher than that in patients with measles (mean: 36.3 nmol/L) and influenza (18.8 nmol/L) and in healthy controls (6.7 nmol/L; P < 0.001). In the patients with confirmed DF, an early neopterin elevation was detected already at the first day after the onset of symptoms and rose to a maximum level of 54.3 nmol/L 4 days after the onset. Higher increase of neopterin level in DF patients was associated with longer duration of fever and thus predicted the clinical course of the disease. Conclusions: Neopterin concentrations were found significantly higher in DF patients compared with healthy controls and also with other viral infections (P < 0.001) and may allow early assessment of the severity of DF. (C) 2005 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
ISSN 0163-4453
Rights Journal of Infection © 2006 Harcourt (Elsevier). The Journal's web site is located at
Language English
Format Article
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