Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/67686

Theoretical Studies on the Regioselectivity of Iridium-Catalyzed 1,3-Dipolar Azide-Alkyne Cycloaddition Reactions

Authors Luo, Cbong
Jia, Guochen View this author's profile
Sun, Jianwei View this author's profile
Lin, Zhenyang View this author's profile
Issue Date 2014
Source Journal of organic chemistry , v. 79, (24), December 2014, p. 11970-11980
Summary Iridium-catalyzed cycloaddition of thioalkynes and bromoalkynes with azides have been investigated with the aid of density functional theory (DFT) calculations at the M06 level of theory. Our investigation focused on the different regioselectivity observed for the reactions of the two classes of alkynes. The DFT results have shown that the mechanisms of cycloaddition reactions using thioalkynes and bromoalkynes as substrates are similar yet different. The reactions of thioalkynes occur via a metallabicyclic Ircarbene intermediate formed through alkyneazide oxidative coupling via attack of the azide terminal nitrogen toward the beta alkyne carbon, whose carbene ligand is stabilized by an alkylthio/arylthio substituent. Reductive elimination from the intermediate leads to the formation of the experimentally observed 5-sulfenyltriazole. In the reactions of bromoalkynes RC=CBr, the reaction mechanism involves the initial formation of a six-membered-ring metallacycle intermediate in the oxidative coupling step. The six-membered-ring intermediate then undergoes isomerization via migrating the terminal azide nitrogen from the beta carbon to the a carbon to form a much less stable metallabicyclic Ircarbene species from which reductive elimination gives 4-bromotriazole.
ISSN 0022-3263
Language English
Format Article
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