A POINT-OF-CARE IMMUNOTEST FOR BEDSIDE DETERMINATION OF HEART-TYPE FATTY ACID-BINDING PROTEIN
Chan, Cangel Pui-Yee
Cautherley, George W. H.
Glatz, Jan F. C.
|Source||Analytical letters, v. 43, (4), 2010, p. 735-744|
|Summary||Heart-type fatty acid-binding protein (H-FABP) is a small cytosolic protein abundant in heart muscle cells. It offers great potential as a sensitive biomarker for early diagnosis of acute myocardial infarction (AMI). Ninety-one patients presented to the Emergency Department suspected of AMI with a median symptom onset of 6 h (IQR 3-20 h), of which 75 (82.4\%) had AMI. The diagnostic performance of a point-of-care immunotest for H-FABP was compared with those of cardiac troponin T (cTnT), creatinine kinase MB (CK-MB), and myoglobin. The H-FABP immunotest was found to have a significant better sensitivity than the other markers and a better specificity than myoglobin and CK-MB. The H-FABP Immunotest gave the greatest area under the receiver operating characteristic (ROC) curve (0.864) for those admitted within 6 h after the onset of symptoms; whereas, cTnT gave the greatest area under the ROC curve (0.936) for those admitted 6-24 h. The H-FABP was also found to be the most efficient marker to diagnose patients suspected of AMI without ST-elevation and with a negative cTnT. Early detection of H-FABP using the point-of-care immunotest in patients suspected of AMI may allow more accurate targeting of appropriate therapy and considerable cost savings than the current diagnostic tests.|
|Rights||This is a preprint of an article whose final and definitive form has been published in the Analytical Letters c 2010 copyright Taylor & Francis; Analytical Letters is available online at: http://www.informaworld.com|
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