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Functionalized AIE Nanoparticles with Efficient Deep-red emission, Mitochondria Specificity, Cancer Cell Selectivity and Multiphoton Susceptibility

Authors Nicol, Alexander William HKUST affiliated (currently or previously)
Qin, Wei HKUST affiliated (currently or previously)
Kwok, Tsz Kin View this author's profile
Burkhartsmeyer, Jeffrey Mark HKUST affiliated (currently or previously)
Zhu, Zhenfeng
Su, Huifang HKUST affiliated (currently or previously)
Luo, Wenwen
Lam, Wing Yip View this author's profile
Qian, Jun
Wong, Kam Sing View this author's profile
Tang, Benzhong View this author's profile
Issue Date 2017
Source Chemical Science , v. 8, (6), June 2017, p. 4634-4643
Summary Multiphoton microscopy is an exciting tool for biomedical research because it can be used to image single cells in vivo due to its greater penetration depth, lower phototoxicity and higher resolution when compared to confocal laser scanning microscopy. This helps researchers understand how certain cells change over time and evaluate the efficacy of different therapies. Herein, we report a new AIE luminogen (AIEgen), abbreviated as TPE-TETRAD, with a favorable absorption and efficient deep-red emission in the solid state. TPE-TETRAD possesses a high two-photon absorption cross-section (313 MG at 830 nm) and a rich array of non-linear optical properties including aggregation-induced three-photon luminescence. Biotinylated TPE-TETRAD nanoparticles are also fabricated and applied to stain mitochondria in live cancer cells with high specificity. The purpose of this study is to characterize a novel deep-red AIEgen and fabricate biotinylated nanoparticles for applications as (1) biocompatible and photostable AIE probes for specific mitochondria imaging and (2) multiphoton imaging probes suitable for two/three-photon fluorescence microscopy. © The Royal Society of Chemistry 2017.
ISSN 2041-6520
Language English
Format Article
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