Please use this identifier to cite or link to this item: http://hdl.handle.net/1783.1/86198

Exceptionally High Payload of the IR780 Iodide on Folic Acid-Functionalized Graphene Quantum Dots for Targeted Photothermal Therapy

Authors Li, Shuhua
Zhou, Shixin
Li, Yunchao
Li, Xiaohong
Zhu, Jia
Fan, Louzhen
Yang, Shihe View this author's profile
Issue Date 2017
Source ACS Applied Materials and Interfaces , v. 9, (27), 2017, p. 22332-22341
Summary The IR780 iodide (IR780) is recognized as an effective theranostic agent for simultaneous near-infrared fluorescence imaging and photothermal therapy (PTT). However, the rigid chloro-cyclohexenyl ring makes IR780 insoluble in almost all pharmaceutically acceptable solvents, which inevitably limits its clinical application. We report folic acid (FA)-functionalized graphene quantum dots (GQDs-FA) containing a large and intact sp2 domain with carboxyl groups around the edge. Such GQDs-FA possess exceptionally high loading capacity for IR780 via strong π-π stacking interactions, and the water solubility of IR780 is improved by over 2400-fold after loading onto GQDs-FA (IR780/GQDs-FA). IR780/GQDs-FA with an improved photostability, an enhanced tumor-targeting ability, and a high photothermal conversion efficiency of 87.9% were capable of producing sufficient hyperthermia to effectively kill cancer cells and completely eradicate tumors upon 808 nm laser irradiation. The present IR780/GQDs-FA may open up great opportunities for the effective PTT to treat cancer. © 2017 American Chemical Society.
Subjects
ISSN 1944-8244
Language English
Format Article
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